IGF-1C hydrogel improves the therapeutic effects of MSCs on colitis in mice through PGE<sub>2</sub>-mediated M2 macrophage polarization
Xiaocang Cao, Liyun Duan, Huixing Hou, Yue Liu, Shang Chen, Shuaiqiang Zhang, Yuanyuan Liu, Chen Wang, Xin Qi, Na Liu, Zhibo Han, Dekui Zhang, Zhongchao Han, Zhikun Guo, Qiang Zhao, Zongjin Li
Abstract
-mediated M2 macrophage polarization. Molecular imaging approaches and therapeutic strategies for hydrogel application provide a versatile platform for exploring the promising therapeutic potential of MSCs in the treatment of IBD.
Topics & Concepts
Mesenchymal stem cellColitisMacrophage polarizationChemistryBioluminescence imagingM2 MacrophageIn vivoCancer researchInflammatory bowel diseaseProstaglandin E2MacrophagePharmacologyImmunologyIn vitroMedicinePathologyInternal medicineTransfectionBiologyBiochemistryDiseaseGeneLuciferaseBiotechnologyMesenchymal stem cell researchNeonatal Respiratory Health ResearchImmune cells in cancer