Asymmetric Catalytic 1,2‐Dihydrophosphination of Secondary 1,2‐Diphosphines – Direct Access to Free <i>P</i>*‐ and <i>P</i>*,<i>C</i>*‐Diphosphines
Ronald Hong Xiang Teo, Houguang Jeremy Chen, Yongxin Li, Sumod A. Pullarkat, Pak‐Hing Leung
Abstract
Abstract A 1,2‐dihydrophosphination of bis(phenylphosphino)ethane with a wide range of activated olefins was achieved in a catalytic manner with enantiomeric and diastereomeric excess of up to >99% and 44% respectively. The protocol can be extended to selected substrates leading to free P ‐ and C ‐chiral 1,2‐diphosphines. The synthesized ligands can also undergo direct complexation onto palladium affording complexes with complete retention of stereo‐integrity. magnified image
Topics & Concepts
DiphosphinesChemistryDiastereomerCatalysisPalladiumMedicinal chemistryStereochemistryOrganic chemistryAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisOrganophosphorus compounds synthesis