Room-temperature C–H bond alkynylation by merging cobalt and photocatalysts
Rajib Mandal, Nagaraju Barsu, Bholanath Garai, Abir Das, Dmitry S. Perekalin, Basker Sundararaju
Abstract
-C-H alkynylation of easily accessible benzamide derivatives using alkynyl bromides at room temperature by merging cobalt and photocatalysts. The diverse reactivity of various alkynyl bromides towards the C-H alkynylation and competing C-H/N-H bond annulation reactions has been demonstrated to give the corresponding products in good yields with excellent functional group tolerance.
Topics & Concepts
AlkynylationAnnulationCobaltBenzamideChemistryReactivity (psychology)Medicinal chemistryCombinatorial chemistryPhotochemistryOrganic chemistryCatalysisAlternative medicineMedicinePathologyCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSynthesis and Catalytic Reactions