Antiviral supramolecular polymeric hydrogels by self-assembly of tenofovir-bearing peptide amphiphiles
Maya K. Monroe, Han Wang, Caleb F. Anderson, Meng Qin, Chloe L. Thio, Charles Flexner, Honggang Cui
Abstract
gelation and release. We envision the use of this system as an important delivery platform for the sustained, linear release of TFV at rates that can be precisely tuned to attain therapeutically relevant TFV plasma concentrations.
Topics & Concepts
ProdrugAmphiphilePeptideSupramolecular chemistryChemistrySelf-healing hydrogelsIn vitroDrug deliveryTenofovirAqueous solutionCombinatorial chemistryReverse transcriptaseSelf-assemblyConjugateOligopeptideNucleotideBiophysicsNanotechnologyHuman immunodeficiency virus (HIV)BiochemistryVirologyMaterials scienceCopolymerOrganic chemistryMoleculeRNABiologyMathematicsGenePolymerMathematical analysisSupramolecular Self-Assembly in MaterialsRNA Interference and Gene DeliveryPolydiacetylene-based materials and applications