Glycerophosphodiesterase 3 (GDE3) is a lysophosphatidylinositol-specific ectophospholipase C acting as an endocannabinoid signaling switch
Fabienne Briand‐Mésange, Véronique Pons, Sophie Allart, Julien Masquelier, Gaëtan Chicanne, Nicolas Beton, Bernard Payrastre, Giulio G. Muccioli, Jérôme Ausseil, J. Davignon, Jean‐Pierre Salles, Hugues Chap
Abstract
relevance of our findings. These data thus open a new research avenue in the field of endocannabinoid generation and reinforce the view of GPR55 and LPI being genuine actors of the endocannabinoid system.
Topics & Concepts
Endocannabinoid systemDiacylglycerol lipaseMonoacylglycerol lipaseLipid signalingCannabinoid receptorBiochemistryLysophosphatidic acidDiacylglycerol kinaseArachidonic acidBiologyCell biologySignal transductionPhospholipase A2Chemistry2-ArachidonoylglycerolReceptorEnzymeProtein kinase CAgonistCannabis and Cannabinoid ResearchPancreatic function and diabetesNeurotransmitter Receptor Influence on Behavior