Design, synthesis and development of a dual inhibitor of Topoisomerase 1 and poly (ADP-ribose) polymerase 1 for efficient killing of cancer cells
Ananda Guha Majumdar, Shikha Shree, Amit Das, Binita K. Kumar, Papiya Dey, Mahesh Subramanian, Birija Sankar Patro
Topics & Concepts
PARP1ChemistryPoly ADP ribose polymeraseTopoisomerasePolymeraseCancer cellDNA damageCytotoxicityProgrammed cell deathApoptosisIn vitroDNABiochemistryPharmacologyCancerBiologyGeneticsCancer therapeutics and mechanismsPARP inhibition in cancer therapyAdvanced biosensing and bioanalysis techniques