circKIF4A sponges miR-127 to promote ovarian cancer progression
Shunliang Sheng, Yi Hu, Furong Yu, Wenjuan Tong, Shufen Wang, Yanlin Cai, Jiayu Zhu
Abstract
. The results revealed that circKIF4A was highly expressed in ovarian cancer tissues. Knockdown of circKIF4A suppressed cell proliferation and migration in ovarian cancer. Subsequent mechanism study revealed that circKIF4A acted as a competitive endogenous RNA (ceRNA) to promoted ovarian cancer progression by sponging miR-127 and upregulated the expression of Junctional adhesion molecule 3 (JAM3). Therefore, circKIF4A could be a novel biomarker and therapeutic target for ovarian cancer.
Topics & Concepts
Ovarian cancerGene knockdownCancerCompeting endogenous RNACancer researchBiologyTumor progressionBiomarkerDownregulation and upregulationGeneLong non-coding RNAGeneticsCircular RNAs in diseasesMicroRNA in disease regulationCancer-related molecular mechanisms research