Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France
Christophe Rodriguez, Guillaume Gricourt, Mélissa N’Debi, Vanessa Démontant, Lila Poiteau, Sonia Burrel, David Boutolleau, Paul‐Louis Woerther, Vincent Cálvez, Sébastian Ströer, Jean–Michel Pawlotsky
Abstract
We report the discovery of a new orthobunyavirus, Cristoli virus, by means of shotgun metagenomics. The virus was identified in an immunodepressed patient with fatal encephalitis. Full-length genome sequencing revealed high-level expression of a virulence factor, possibly explaining the severity of the infection. The patient's recent history suggests circulation in France.
Topics & Concepts
OrthobunyavirusVirusVirologyEncephalitisBiologyMetagenomicsVirulenceGeneticsGeneViral Infections and VectorsMosquito-borne diseases and controlParvovirus B19 Infection Studies