Itraconazole Coated Super Paramagnetic Iron Oxide Nanoparticles for Antimicrobial Studies
Antony V. Samrot, Chamarthy Sai Sahithya, D Sruthi, Jenifer Selvarani A, Ponnaiah Paulraj, Petchi Iyappan, Sajeesh Pattammadath, Sajna Keeyari Purayil, Pazhayakath Thevarkattil, Mohamed Javad, Kasirajan Kasipandian, A Shnoudeh, I Hamad, R Abdo, L Qadumii, A Jaber, H Surchi, S Alkelany, Synthesis, P Raji, A Samrot, K Bhavya, M Sharan, S Priya, P Paulraj, A Samrot, P Senthilkumar, S Rashmitha, P Veera, C Sahithya, A Samrot, N Shobana, S Kumar, G Narendrakumar, Production, P Raji, A Samrot, D Keerthana, S Karishma, A Samrot, N Shobana, D Sruthi, C Sahithya, A Samrot, P Raji, A Selvarani, P Nishanthini, A Samrot, C Silky; Ignatious, P Raji, C Saipriya, A Selvarani, R Gandham, P Raji, B Rohan, D Kumar, K Sharma, D Keerthana, S Karishma, P Iyappan, R Thirumurugan, A Samrot, P Ponniah, S Pattammadath, K Purayil, P Javad, P Prakash, D Kumar, P Raji, B Rohan, R Gandham, K Sharma, D Keerthana, S Karishma, A Samrot, P Ponniah, R Thirumurugan, S Pattammadath, A Selvarani, P Prakash, C Justin, A Samrot, P Sruthi, C Sahithya, K Bhavya, C Saipriya, P Sruthi, C Sahithya, C Justin, C Saipriya, K Bhavya, P Senthilkumar, A Samrot, C Justin, A Samrot, A Annamalai, R Bhattacharya, P; Sathiyamoorthy, C Sahithya, C Justin
Abstract
In this present study, Superparamagnetic Iron Oxide Nanoparticles (SPIONs) were produced using FeCl3 and FeCl2 which were reduced to iron oxides using NaOH and ammonia solution (chemical co-precipitation). These naked SPIONs were further fabricated to form drug laden core-shell for controlled drug release and delivery. The fabrication was achieved by subjugating the naked SPIONs for oleic acid functionalization, drug tagging (Itraconazole) and finally encapsulated with a microbial derived polyester namely Polyhydroxybutyrate (PHB). Every stage of fabrication was characterized by scanning electron microscopy (SEM). The core-shell produced was checked for drug release kinetics, antibacterial and antifungal activities. These synthesized core-shells were carrying the drug and showed a slow drug release profile. The antimicrobial studies against bacteria - Pseudomonas aeruginosa & Brevibacillus brevis and fungi - Candida albicans by diffusion method proved that the core-shells inhibited bacterial and fungal activity. Furthermore, the naked SPIONs was found to be a good contrasting agent in X-ray imaging.