Intersections between innate immune response and gastric cancer development
Franz Villarroel‐Espíndola, Troy Ejsmentewicz, Roxana González‐Stegmaier, Roddy Jorquera, Esteban Salinas
Abstract
strains. Gastrointestinal epithelial cells express several Toll-like receptors and determine the first defensive line against pathogens, and have been also described as mediators of tumorigenesis. However, other molecules, such as cytokines related to inflammation and innate immunity, including immune checkpoint molecules, interferon-gamma pathway and NETosis have been associated with an increased risk of GC. Therefore, this review will explore innate immune activation in the context of premalignant lesions of the gastric epithelium and established gastric tumors.
Topics & Concepts
Innate immune systemImmunologyImmune systemCancerInflammationTumor microenvironmentHelicobacter pyloriBiologyContext (archaeology)Proinflammatory cytokineMalignancyCarcinogenesisCancer researchMedicinePathologyInternal medicinePaleontologyHelicobacter pylori-related gastroenterology studiesGalectins and Cancer BiologyIL-33, ST2, and ILC Pathways