Unstable regulatory T cells, enriched for naïve and Nrp1<sup>neg</sup>cells, are purged after fate challenge
Steffie Junius, Adamantios V. Mavrogiannis, Pierre Lemaître, Margaux Gerbaux, Frederik Staels, Vanshika Malviya, Oliver T. Burton, Václav Gergelits, K. N. Singh, Raúl Y. Tito, Jeroen Raes, Stéphanie Humblet‐Baron, Adrian Liston, Susan Schlenner
Abstract
Lymphophenic fate challenge purges incompletely committed regulatory T cells, a subset enriched for naïve neuropilin-1–negative T reg .
Topics & Concepts
Neuropilin 1Cell biologyBiologyMolecular biologyChemistryCancer researchVEGF receptorsVascular endothelial growth factorT-cell and B-cell ImmunologyImmune Cell Function and InteractionCAR-T cell therapy research