Human Papillomavirus Genome Copy Number Is Maintained by S-Phase Amplification, Genome Loss to the Cytosol during Mitosis, and Degradation in G <sub>1</sub> Phase
Malgorzata Bienkowska‐Haba, Katarzyna Zwolińska, Timothy R. Keiffer, Rona S. Scott, Martin Sapp
Abstract
HPV genome maintenance is currently thought to be achieved by regulating the expression and activity of the viral replication factors E1 and E2. In addition, the E8^E2 repressor has been shown to be important for restricting genome copy numbers by competing with E1 and E2 for binding to the viral origin of replication and by recruiting repressor complexes.
Topics & Concepts
BiologyGenomeRepressorMitosisGeneticsDNA replicationViral replicationReplication (statistics)Cell biologyGeneVirologyVirusGene expressionCervical Cancer and HPV ResearchPlant Virus Research StudiesHerpesvirus Infections and Treatments