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Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögren's disease

Sarthak Gupta, Eiko Yamada, Hiroyuki Nakamura, Paola Pérez, Thomas Pranzatelli, Kalie Dominick, Shyh-Ing Jang, Mehdi Abed, Daniel Martı́n, Peter D. Burbelo, Changyu Zheng, B.A. French, Ilias Alevizos, Zohreh Khavandgar, Margaret Beach, Eileen Pelayo, Brian Walitt, Sarfaraz Hasni, Mariana J. Kaplan, Mayank Tandon, M. Teresa Magone, David E. Kleiner, John A. Chiorini, Alan N. Baer, Blake M. Warner

2024Annals of the Rheumatic Diseases42 citationsDOIOpen Access PDF

Topics & Concepts

Janus kinaseSTAT proteinJAK-STAT signaling pathwaystatMedicineSTAT3ImmunologyInterferonSTAT1InflammationImmune systemSignal transductionAutoimmune diseaseJanus kinase 1Activator (genetics)Cancer researchCytokineReceptorBiologyInternal medicineAntibodyCell biologyTyrosine kinaseSalivary Gland Disorders and FunctionsOlfactory and Sensory Function StudiesSystemic Lupus Erythematosus Research
Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögren's disease | Litcius