Click-to-Release: Cleavable Radioimmunoimaging with [<sup>89</sup>Zr]Zr-DFO-<i>Trans</i>-Cyclooctene-Trastuzumab Increases Tumor-to-Blood Ratio
Maria Vlastara, Raffaella Rossin, Freek J. M. Hoeben, Kim E. de Roode, Milou Boswinkel, Laurens H. J. Kleijn, James Nagarajah, Mark Rijpkema, Marc S. Robillard
Abstract
-cyclooctene-tetrazine click-to-release chemistry to release a radioactive chelator from a mAb in mice to increase tumor-to-blood ratios. Our results suggest that click-cleavable radioimmunoimaging may allow for substantially shorter intervals in PET imaging with full mAbs, reducing radiation doses and potentially even enabling same day imaging.
Topics & Concepts
TrastuzumabChemistryRadiochemistryMaterials scienceNuclear chemistryMedicineInternal medicineCancerBreast cancerRadiopharmaceutical Chemistry and ApplicationsMonoclonal and Polyclonal Antibodies ResearchPeptidase Inhibition and Analysis