Adhesion G protein-coupled receptor VLGR1/ADGRV1 regulates cell spreading and migration by mechanosensing at focal adhesions
Deva Krupakar Kusuluri, Baran E. Güler, Barbara Knapp, Nicola Horn, Karsten Boldt, Marius Ueffing, Gabriela Aust, Uwe Wolfrum
Abstract
mutant mice. VLGR1 depletion reduces cell spread and migration kinetics as well as the response to mechanical stretch characterizing VLGR1 as a metabotropic mechanosensor in FAs. Our data reveal a critical role of VLGR1 in the FA function and enlighten potential pathomechanisms in diseases related to VLGR1.
Topics & Concepts
HaploinsufficiencyInteractomeFocal adhesionCell biologyCell adhesionReceptorCell migrationBiologyProteomicsChemistryCellPhenotypeGeneticsSignal transductionGeneCell Adhesion Molecules ResearchCellular Mechanics and InteractionsReceptor Mechanisms and Signaling