Enzyme-Constrained Models and Omics Analysis of <i>Streptomyces coelicolor</i> Reveal Metabolic Changes that Enhance Heterologous Production.
Snorre Sulheim, Tjaša Kumelj, Dino van Dissel, Ali Salehzadeh‐Yazdi, Chao Du, Gilles P. van Wezel, Kay Nieselt, Eivind Almaas, Alexander Wentzel, Eduard J. Kerkhoven
Abstract
for heterologous production of novel compounds.
Topics & Concepts
Streptomyces coelicolorHeterologousBiologyComputational biologyTranscriptomeGeneMetabolomeHeterologous expressionMetagenomicsStreptomycesProteomicsPolyketideGeneticsMetabolomicsGene expressionBioinformaticsBacteriaBiosynthesisRecombinant DNAMicrobial Natural Products and BiosynthesisMicrobial Metabolic Engineering and BioproductionRNA and protein synthesis mechanisms