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Impact of Tigecycline on C. difficile Outcomes: Case Series and Propensity-Matched Retrospective Study

Emma C. Phillips, Cirle A. Warren, Z. Jennie, Gregory R. Madden

2022Antimicrobial Agents and Chemotherapy14 citationsDOIOpen Access PDF

Abstract

This case series and propensity-matched cohort study on the use of tigecycline in Clostridioides difficile infection (CDI) evaluated the effect of tigecycline on 30-day mortality. Adjusted for ATLAS Score, hypotension, treatment time period, and serum lactate, tigecycline did not significantly improve 30-day mortality (odds ratio: 0.89; 95% confidence interval: 0.25–3.12; P = 0.853).

Topics & Concepts

TigecyclineRetrospective cohort studyMedicinePropensity score matchingSeries (stratigraphy)Internal medicineIntensive care medicineAntibioticsMicrobiologyBiologyPaleontologyClostridium difficile and Clostridium perfringens researchPharmacological Effects of Natural CompoundsMicroscopic Colitis
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