Synthesis of C4-Aminated Carbazoles and Their Derivatives via Pd/NBE Chemistry
Bo‐Sheng Zhang, Sheng-Yan Zhao, Shun‐Xi Li, Wan-Yuan Jia, Yu-Xi Yang, Yiming Wang, Xue‐Ya Gou, Yong‐Min Liang, Xi‐Cun Wang, Zheng‐Jun Quan
Abstract
Carbazole, as one of the most important organic frameworks, has been used in optoelectronic materials and biochemistry. However, the synthesis of C4-substituted carbazole has always been an unsolved problem. This report describes the one-step synthesis of C4-aminated carbazoles and their derivatives through the series reaction of C-H amination and arylation. The substrate scope is wide. C4-Amino carbazoles substituted by C2, C6, C7, and C8 methyl groups, especially carbazole derivatives of fused rings, pyridine, and dibenzofuran, can be synthesized.
Topics & Concepts
CarbazoleDibenzofuranAminationChemistryPyridineCombinatorial chemistrySubstrate (aquarium)Organic chemistryCatalysisOceanographyGeologyCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesCatalytic Cross-Coupling Reactions