Biomolecular condensates with liquid properties formed during viral infections
Damien Glon, Benjamin Leonardon, Ariane Guillemot, Aurélie Albertini, Cécile Lagaudrière‐Gesbert, Yves Gaudin
Abstract
During a viral infection, several membraneless compartments with liquid properties are formed. They can be of viral origin concentrating viral proteins and nucleic acids, and harboring essential stages of the viral cycle, or of cellular origin containing components involved in innate immunity. This is a paradigm shift in our understanding of viral replication and the interaction between viruses and innate cellular immunity.
Topics & Concepts
Innate immune systemBiologyNucleic acidViral replicationImmunityViral infectionIntrinsic immunityVirologyCell biologyImmunologyVirusImmune systemGeneticsRNA Research and Splicinginterferon and immune responsesRNA modifications and cancer