Hexokinases in cancer and other pathologies
Dong Guo, Ying Meng, Xiaoming Jiang, Zhimin Lu
Abstract
Glucose metabolism is indispensable for cell growth and survival. Hexokinases play pivotal roles in glucose metabolism through canonical functions of hexokinases as well as in immune response, cell stemness, autophagy, and other cellular activities through noncanonical functions. The aberrant regulation of hexokinases contributes to the development and progression of pathologies, including cancer and immune diseases.
Topics & Concepts
AutophagyImmune systemBiologyCancerMetabolismCancer cellCancer researchCell biologyBiochemistryImmunologyGeneticsApoptosisCancer, Hypoxia, and MetabolismPancreatic function and diabetesMetabolism, Diabetes, and Cancer