4-(3-Alkyl/benzyl-guanidino)benzenesulfonamides as selective carbonic anhydrase VII inhibitors
Morteza Abdoli, Simone Giovannuzzi, Claudiu T. Supuran, Raivis Žalubovskis
Abstract
-s in the subnanomolar range and good selectivity indexes for inhibiting the target versus the off-target isoforms.
Topics & Concepts
Carbonic anhydraseGene isoformSelectivityIsozymeNeuropathic painAlkylChemistrySulfonamideInhibitory postsynaptic potentialEnzymeStereochemistryPharmacologyBiochemistryMedicineInternal medicineGeneCatalysisOrganic chemistryEnzyme function and inhibitionCholinesterase and Neurodegenerative DiseasesSynthesis and Catalytic Reactions