<i>Toxoplasma</i> Uses GRA16 To Upregulate Host c-Myc
Michael W. Panas, John C. Boothroyd
Abstract
The proto-oncogene c- Myc plays a crucial role in the growth and division of many animal cells. Previous studies have identified an active upregulation of c-Myc by Toxoplasma tachyzoites, suggesting the existence of one or more exported “effector” proteins. The identity of such an effector, however, has not previously been known. Here, we show that a previously known secreted protein, GRA16, plays a crucial role in c-Myc upregulation. This finding will enable further dissection of the precise mechanism and role of c-Myc upregulation in Toxoplasma -infected cells.
Topics & Concepts
IntracellularHost (biology)Intracellular parasitePathogenDownregulation and upregulationBiologyCell biologyVirologyMicrobiologyGeneticsGeneToxoplasma gondii Research StudiesCytomegalovirus and herpesvirus researchHerpesvirus Infections and Treatments