Molecular insights using spatial transcriptomics of the distal lung in congenital diaphragmatic hernia
Krithika Lingappan, Oluyinka O. Olutoye, Abiud Cantu, Manuel Cantu Gutierrez, Nahir Cortes‐Santiago, J. D. Hammond, Jamie Gilley, Joselyn Rojas Quintero, Hui Li, Francesca Polverino, Jason P. Gleghorn, Sundeep G. Keswani
2023American Journal of Physiology-Lung Cellular and Molecular Physiology13 citationsDOIOpen Access PDF
Abstract
This is the first use of spatial transcriptomics in patients with congenital diaphragmatic hernia (CDH) that identifies the contribution of different lung cellular subpopulations in CDH pathophysiology and highlights sex-specific differences.
Topics & Concepts
Congenital diaphragmatic herniaPathophysiologyLungTranscriptomeDiaphragmatic breathingDiaphragmatic herniaMedicineHerniaBioinformaticsPathologyInternal medicineBiologySurgeryGeneGene expressionGeneticsFetusPregnancyAlternative medicineCongenital Diaphragmatic Hernia StudiesNeonatal Respiratory Health ResearchCongenital heart defects research