A WNT7B-m6A-TCF7L2 positive feedback loop promotes gastric cancer progression and metastasis
Qian Gao, Liuyang Yang, Aolin Shen, Yang Li, Yongxiang Li, Shilian Hu, Runhuai Yang, Xiangting Wang, Xuebiao Yao, Guodong Shen
Abstract
Signal transduction takes the responsibility of translating extracellular information into specific cellular activities, enabling cells, including cancer cells, to respond exquisitely to extracellular guidance cues. N 6 -methyladenosine (m 6 A), the most pervasive and abundant modification within eukaryotic mRNAs, is known to have specific effects on cellular activities relevant to cancer. 1 Despite the fact that m 6 A methylation is a dynamic event involving a series of enzymes, it remains unknown whether signal transduction, much less extracellular signaling molecules, uses m 6 A methylation as an effector mechanism in cancer.