Injectable, photoresponsive hydrogels for delivering neuroprotective proteins enabled by metal-directed protein assembly
Bojing Jiang, Xiaotian Liu, Chao Yang, Zhongguang Yang, Jiren Luo, Songzi Kou, Kai Liu, Fei Sun
Abstract
-coordinated gels decorated with leukemia inhibitory factor into injured mouse optic nerves led to prolonged cellular signaling and enhanced axon regeneration. This study illustrates a powerful strategy for designing injectable biomaterials.
Topics & Concepts
NeuroregenerationNeuroprotectionSelf-healing hydrogelsChemistryNanotechnologyMaterials scienceNeuroscienceBiologyPolymer chemistrySupramolecular Self-Assembly in MaterialsBiochemical and Structural CharacterizationNerve injury and regeneration