New Insights into IGF-1 Signaling in the Heart
Wang Soo Lee, E. Dale Abel, Jaetaek Kim
Abstract
Insulin-like growth factor-1 (IGF-1) signaling has multiple physiological roles in cellular growth, metabolism, and aging. Myocardial hypertrophy, cell death, senescence, fibrosis, and electrical remodeling are hallmarks of various heart diseases and contribute to the progression of heart failure. This review highlights the critical role of IGF-1 and its cognate receptor in cardiac hypertrophy, aging, and remodeling.
Topics & Concepts
Heart failureMuscle hypertrophySenescenceFibrosisGrowth factorInsulin-like growth factorSignal transductionCell metabolismBiologyCardiac hypertrophyMyocardial hypertrophyInternal medicineReceptorMedicineEndocrinologyCell biologyMetabolismCardiovascular Function and Risk FactorsMetabolism, Diabetes, and CancerCardiac Fibrosis and Remodeling