Bryostatin-1 Decreases HIV-1 Infection and Viral Production in Human Primary Macrophages
Laurent Hany, Marc‐Olivier Turmel, Corinne Barat, Michel Ouellet, Michel J. Tremblay
Abstract
study, we discovered encouraging antireplicative features of distinct LRAs in human macrophages. We also described a new viral production inhibition mechanism by protein kinase C agonists that is specific to myeloid cells. This study provides new insights into HIV-1 propagation restriction potentials by LRAs in human macrophages and underline the importance of assessing latency reversal strategy on all HIV-1-targeted cells.
Topics & Concepts
BiologyHuman immunodeficiency virus (HIV)VirologyLatency (audio)Virus latencyAntiretroviral therapyImmunologyBryostatin 1Viral replicationVirusViral loadCell biologySignal transductionEngineeringElectrical engineeringProtein kinase CHIV Research and TreatmentHIV/AIDS drug development and treatmentHIV-related health complications and treatments