Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections
Isabella Santi, Pablo Manfredi, Enea Maffei, Adrian Egli, Urs Jenal
Abstract
against different classes of antibiotics and that it generally precedes and promotes resistance development. The rapid evolution of tolerance during treatment regimens may thus act as a strong driving force to accelerate antibiotic resistance development. To successfully counter resistance, diagnostic measures and novel treatment strategies will need to incorporate the important role of antibiotic tolerance.
Topics & Concepts
Pseudomonas aeruginosaAntibiotic resistanceAntibioticsIntensive care medicineMedicineOrgan transplantationMicrobiologyTransplantationBiologyBacteriaGeneticsInternal medicineAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensingVibrio bacteria research studies