A Comprehensive Overview of the Developments of Cdc25 Phosphatase Inhibitors
Ahmed B. Abdelwahab, Eslam R. El‐Sawy, Atef G. Hanna, Denyse Bagrel, Gilbert Kirsch
Abstract
Cdc25 phosphatases have been considered promising targets for anticancer development due to the correlation of their overexpression with a wide variety of cancers. In the last two decades, the interest in this subject has considerably increased and many publications have been launched concerning this issue. An overview is constructed based on data analysis of the results of the previous publications covering the years from 1992 to 2021. Thus, the main objective of the current review is to report the chemical structures of Cdc25s inhibitors and answer the question, how to design an inhibitor with better efficacy and lower toxicity?
Topics & Concepts
Cdc25Variety (cybernetics)Computational biologyPhosphataseData scienceComputer scienceBiologyCancerPhosphorylationBiochemistryGeneticsCell cycleArtificial intelligenceCyclin-dependent kinase 1Protein Tyrosine PhosphatasesBiochemical and Molecular ResearchPeptidase Inhibition and Analysis