Chlorogenic acid and β-glucan from highland barley grain ameliorate β-cell dysfunction <i>via</i> inhibiting apoptosis and improving cell proliferation
Zehua Liu, Бо Лі
Abstract
-ATP levels back to normal levels, and BG at 300 mg per kg BW restored β-cell insulin contents back to normal levels in IGT mice. Additionally, the combination of CA and BG had an additive effect on ameliorating β-cell dysfunction. These results help develop whole highland barley grain as a functional food for preventing type 2 diabetes by ameliorating pancreatic β-cell damage.
Topics & Concepts
ApoptosisCell growthProtein kinase BEndocrinologyGSK-3Internal medicineInsulinGlucose homeostasisPI3K/AKT/mTOR pathwayCellChemistryInsulin resistanceSignal transductionBiologyBiochemistryMedicinePancreatic function and diabetesDiet, Metabolism, and DiseaseNatural Antidiabetic Agents Studies