Disruption of the Intestinal Mucosal Barrier Induced by High Fructose and Restraint Stress Is Regulated by the Intestinal Microbiota and Microbiota Metabolites
Jiayu Yu, Tianlong Liu, Qingyun Guo, Zixu Wang, Yaoxing Chen, Yulan Dong
Abstract
A high-fructose diet aggravated restraint stress-induced changes in the composition of the intestinal microbiome, in which the abundance of A. muciniphila was significantly increased. The high-fructose diet exacerbated restraint stress-induced the changes in the composition of the microbial metabolites, with taurine abundance being downregulated and histamine abundance upregulated.
Topics & Concepts
Akkermansia muciniphilaBarrier functionGut floraBiologyMicrobiologyIntestinal mucosaFructoseMetabolomeIntestinal epitheliumIntestinal DisorderImmunologyCell biologyBiochemistryEpitheliumMetaboliteInternal medicineMedicineDiseaseGeneticsGut microbiota and healthDiet, Metabolism, and DiseaseCannabis and Cannabinoid Research