MicroRNA-30a-5p silencing polarizes macrophages toward M2 phenotype to alleviate cardiac injury following viral myocarditis by targeting SOCS1
Yan Zhang, Shengbao Cai, Xiaoxue Ding, Can Lu, WU Ruo-dan, Haiyan Wu, Yiyi Shang, Mingjie Pang
Abstract
We found in this study that microRNA (miR)-30a-5p inhibition might improve cardiac injury following viral myocarditis (VMC) by accelerating M2 polarization of macrophages via SOCS1 upregulation. Furthermore, the anti-inflammatory mechanisms of miR-30a-5p inhibition may contribute to the development of new therapeutic strategies for VMC.
Topics & Concepts
Viral MyocarditisGene silencingmicroRNAMyocarditisDownregulation and upregulationMacrophage polarizationPhenotypeMedicineSuppressor of cytokine signaling 1ImmunologyCancer researchBiologyGeneCardiologyInternal medicineSuppressorGeneticsCancerViral Infections and Immunology ResearchSignaling Pathways in DiseaseCardiac Fibrosis and Remodeling