Hepatic lipid droplet-associated proteome changes distinguish dietary-induced fatty liver from glucose tolerance in male mice
Andries Van Woerkom, Dylan Harney, Shilpa R. Nagarajan, Mariam F. Hakeem-Sanni, Jinfeng Lin, Matthew Hooke, Tamara Pilpitel, Gregory J. Cooney, Mark Larance, Darren N. Saunders, Amanda E. Brandon, Andrew J. Hoy
Abstract
This study identified a fatty liver lipid droplet proteome and one associated with glucose tolerance. Notably, glucose intolerance was linked with changes in the ratio of adipose triglyceride lipase to perilipin 5 that is indicative of dysregulation of neutral lipid homeostasis.
Topics & Concepts
ProteomeFatty liverLipid dropletChemistryInternal medicineEndocrinologyBiochemistryBiologyMedicineDiseaseLipid metabolism and biosynthesisAdipose Tissue and MetabolismLiver Disease Diagnosis and Treatment