Development of an inhibitor of the mutagenic SOS response that suppresses the evolution of quinolone antibiotic resistance
Jacob D. Bradbury, Thomas Hodgkinson, Adam Thomas, Omprakash Tanwar, Gabriele La Monica, Vanessa V. Rogga, Luke J. Mackay, Emilia K. Taylor, Kiera Gilbert, Yihua Zhu, A. Sefton, Andrew M. Edwards, Charlotte J. Gray-Hammerton, Gerald R. Smith, Paul M. Roberts, Timothy R. Walsh, Thomas Lanyon‐Hogg
Abstract
Bacterial DNA-damage repair activates the SOS response, which promotes hypermutation and antibiotic resistance. SAR investigation identified OXF-077, a small molecule DNA-repair and SOS-response inhibitor that suppresses resistance evolution.
Topics & Concepts
SOS responseQuinoloneAntibiotic resistanceAntibioticsDNA damageDNA repairSomatic hypermutationMicrobiologyDNABiologyChemistryGeneticsB cellAntibodyAntibiotic Resistance in BacteriaCancer therapeutics and mechanismsDNA Repair Mechanisms