Directed arrangement of siRNA <i>via</i> polymerization-induced electrostatic self-assembly
Liangliang Shen, Yahui Li, Qunzan Lu, Xiaoliang Qi, Xuan Wu, Zaigang Zhou, Jianliang Shen
Abstract
Herein, polymerization-induced electrostatic self-assembly (PIESA) is conducted to mediate the self-assembly behavior of short interfering RNA (siRNA) for the first time. In PIESA, siRNA not only formed a simple electrostatic polyplex with positively charged polycations, but also facilitated directed self-assembly due to the molecular rigidity of siRNA, leading to appealing nanotubes.
Topics & Concepts
PolymerizationChemistryBiophysicsMaterials sciencePolymer chemistryNanotechnologyPolymerOrganic chemistryBiologyAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliverySupramolecular Self-Assembly in Materials