Phenotypic profiling of pancreatic ductal adenocarcinoma plasma-derived small extracellular vesicles for cancer diagnosis and cancer stage prediction: a proof-of-concept study
Wei Zhang, Ling Wang, Dan Li, Douglas Houghton Campbell, Bradley J. Walsh, Nicolle H. Packer, Qing Dong, Erkang Wang, Yuling Wang
Abstract
computerized tomography and magnetic resonance imaging) and also the correlation of cancer stages with CA19-9 (gold standard biomarker) and the sEVs' phenotype signatures. The present proof-of-concept study thus provides an initial investigation of using the proposed SERS assay for PDAC diagnosis and early cancer stage prediction in the clinic.
Topics & Concepts
Pancreatic ductal adenocarcinomaPancreatic cancerExtracellular vesiclesProof of conceptPhenotypeAdenocarcinomaStage (stratigraphy)ExtracellularCancerBiologyCancer researchPathologyInternal medicineMedicineCell biologyComputer scienceBiochemistryGenePaleontologyOperating systemExtracellular vesicles in diseaseMicroRNA in disease regulationPhagocytosis and Immune Regulation