Arsenic binding to human metallothionein-3
Amelia T. Yuan, Martin J. Stillman
Abstract
Arsenic poisoning is of great concern due to its neurological toxicity. We report the thermodynamic and kinetic properties of arsenic binding to the human metallochaperone, metallothionein-3, both in an apo state and Zn 2+ metalated state.
Topics & Concepts
MetallothioneinArsenicChemistryArsenic toxicityArsenic poisoningToxicityBiochemistryEnvironmental chemistryOrganic chemistryGeneTrace Elements in HealthHeavy Metal Exposure and ToxicityElectrochemical Analysis and Applications