Iodine‐Promoted Synthesis of Dipyrazolo/Diuracil‐Fused Pyridines and <i>o</i>‐Amino Diheteroaryl ketones via Oxidative Domino Annulation of 2/4‐Methylazaarenes
Xin‐Ke Zhang, Xiaoyu Miao, Hui‐Ru Jiang, Fei Ge, Jiachen Sun, Rui‐Ying Zhang, Qin Ouyang, Weiyu Fan, Yanping Zhu, Yuanyuan Sun
Abstract
Abstract The iodine‐promoted oxidative domino annulation and carbonylation process has been developed for the synthesis of biologically important azaarene‐substituted bis‐pyrazolo[3,4‐ b :4′,3′‐ e ]pyridines (BPPs), diuracilpyridines and o ‐amino diheteroaryl ketones. The domino procedure proceeded with easily available methyl azaarenes, 5‐aminouracils and substituted 5‐aminopyrazoles. This protocol is a simple and metal‐free approach which exhibits high functional group compatibility and broad substrates scope. Moreover, this transformation can be applied for the preparation of dipyrazolo/diuracil‐fused pyridines on a gram scale. magnified image