Route efficiency assessment and review of the synthesis of β-nucleosides <i>via N</i> -glycosylation of nucleobases

Abstract

Instead of focusing on maximizing glycosylation yield, future syntheses of nucleosides <italic>via N</italic> -glycosylation should aim to use shorter routes, fewer protecting groups and less chromatography to achieve more efficient and sustainable processes, as this E-factor analysis reveals.

Topics & Concepts