Recurrent motifs in pharmaceutical cocrystals involving glycolic acid: X-ray characterization, Hirshfeld surface analysis and DFT calculations
Carmen Alvarez‐Lorenzo, A. Castiñeiras, Antonio Frontera, Isabel García‐Santos, J.M. González-Pérez, J. Niclós‐Gutiérrez, Iria Rodríguez-González, Esther Vílchez-Rodríguez, Jan K. Zaręba
Abstract
Crystallization studies on some pyridinecarboxamides and methylated xanthines with glycolic acid as coformer, were carried out on formation of synthons and their influence on stability and solubility, the energy landscape and stabilization energies.
Topics & Concepts
Glycolic acidSynthonSolubilityCrystallizationCharacterization (materials science)ChemistryComputational chemistryCombinatorial chemistryCrystallographyMaterials scienceOrganic chemistryNanotechnologyBacteriaLactic acidGeneticsBiologyCrystallography and molecular interactionsCrystallization and Solubility StudiesChemical Thermodynamics and Molecular Structure