The <i>Plasmodium</i> Lactate/H <sup>+</sup> Transporter PfFNT Is Essential and Druggable <i>In Vivo</i>
Heledd Davies, Bärbel Bergmann, Philipp Walloch, C Nerlich, Christian Hansen, Sergio Wittlin, Tobias Spielmann, Moritz Treeck, Eric Beitz
Abstract
Malaria parasites in the blood stage express a single transmembrane transport protein for the release of the glycolytic end product l -lactate/H + from the cell. This transporter is a member of the strictly microbial formate-nitrite transporter (FNT) family and a novel putative drug target.
Topics & Concepts
DruggabilityPlasmodium falciparumBiologyIn vivoPlasmodium bergheiTransporterPharmacologyATP-binding cassette transporterBiochemistryGeneGeneticsMalariaImmunologyDrug Transport and Resistance MechanismsMalaria Research and ControlHemoglobinopathies and Related Disorders