Association between Lp(a) and T2D: a Mendelian randomization study
Marcin Goławski, Mateusz Lejawa, Maciej Banach, Jacek Jerzy Jozwiak, Marek Gierlotka, Tadeusz Osadnik
Abstract
Introduction: Blood lipoprotein(a) (Lp(a)) levels have been observed to be inversely correlated with type 2 diabetes (T2D). In this Mendelian randomization (MR) study, the causal impact of genetically predicted Lp(a) on T2D was assessed. Methods: A two-sample MR analysis was conducted. Data were obtained from UK Biobank and FinnGen consortia. Primary analysis was based on an inverse-variance-weighted mean (IVM) approach. Results: = 0.362) in IVM analysis involving data of 563,420 patients. Conclusions: Genetically predicted Lp(a) concentration does not appear to be causally related to the risk of T2D.
Topics & Concepts
MedicineMendelian randomizationRandomizationAssociation (psychology)Type 2 diabetesGeneticsInternal medicineGeneRandomized controlled trialGenetic variantsDiabetes mellitusGenotypeEndocrinologyEpistemologyBiologyPhilosophyLipoproteins and Cardiovascular HealthGenetic Associations and EpidemiologyDiabetes, Cardiovascular Risks, and Lipoproteins