Types of nuclear localization signals and mechanisms of protein import into the nucleus
Juane Lu, Tao Wu, Biao Zhang, Suke Liu, Wenjun Song, Jianjun Qiao, Haihua Ruan
Abstract
Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS-dependent protein recognition, a process necessary for cargo proteins to pass the nuclear envelope through the nuclear pore complex, is facilitated by members of the importin superfamily. Here, we summarized the types of NLS, focused on the recently reported related proteins containing nuclear localization signals, and briefly summarized some mechanisms that do not depend on nuclear localization signals into the nucleus. Video Abstract.
Topics & Concepts
NLSNuclear localization sequenceNuclear transportImportinNucleusCytoplasmNuclear poreCell biologyNuclear proteinRanInner membraneBiologyCell nucleusGeneticsGeneTranscription factorMitochondrionNuclear Structure and FunctionRNA Research and SplicingGenomics and Chromatin Dynamics