Changes in Myocardial Microstructure and Mechanics With Progressive Left Ventricular Pressure Overload
William M. Torres, Shayne C. Barlow, Amber Moore, Lisa Freeburg, Abigail Hoenes, Heather Doviak, Michael R. Zile, Tarek Shazly, Francis G. Spinale
Abstract
This study assessed the regional changes in myocardial geometry, microstructure, mechanical behavior, and properties that occur in response to progressive left ventricular pressure overload (LVPO) in a large animal model. Using an index of local biomechanical function at early onset of LVPO allowed for prediction of the magnitude of left ventricular chamber stiffness (Kc) and left atrial area at LVPO late timepoints. Our study found that LV myocardial collagen content alone was insufficient to identify mechanisms for LV myocardial stiffness with progression to heart failure with preserved ejection fraction (HFpEF). Serial assessment of regional biomechanical function might hold value in monitoring the natural history and progression of HFpEF, which would allow evaluation of novel therapeutic approaches.