Catalysis of a Bis-Caffeine Palladium(II) NHC-Pincer Complex
Oliver Bysewski, Andreas Winter, Ulrich S. Schubert
Abstract
A tridentate bis-NHC Pd complex, based on caffeine, was studied for its catalytic activity. This complex displayed a high catalytic activity in the Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions of aryl halides. The Sonogashira cross-coupling was also investigated but reveals a fast plateauing of the reaction. Aryl iodides as well as aryl bromides react when equipped with either electron-donating or electron-withdrawing substituents. Aryl chlorides, which contained electron-withdrawing groups, were also reactive under the applied conditions.
Topics & Concepts
ArylChemistryCatalysisSonogashira couplingHalidePalladiumPincer movementMedicinal chemistryAryl halideOrganic chemistryCombinatorial chemistryAlkylCatalytic Cross-Coupling ReactionsN-Heterocyclic Carbenes in Organic and Inorganic ChemistrySynthetic Organic Chemistry Methods