Submolecular Ligand Size and Spacing for Cell Adhesion (Adv. Mater. 27/2022)
Yuri Kim, Thomas Myeongseok Koo, Ramar Thangam, Myeongsoo Kim, Woo Young Jang, Nayeon Kang, Sunhong Min, Seong Yeol Kim, Letao Yang, Hyunsik Hong, Hee Joon Jung, Eui Kwan Koh, Kapil D. Patel, Sungkyu Lee, Hong En Fu, Yoo Sang Jeon, Bum Chul Park, Soo Young Kim, Steve Park, Junmin Lee, Luo Gu, Dong‐Hyun Kim, Tae‐Hyung Kim, Ki‐Bum Lee, Woong Kyo Jeong, Ramasamy Paulmurugan, Young Keun Kim, Heemin Kang
Abstract
Cell Adhesion In article number 2110340, Ramasamy Paulmurugan, Young Keun Kim, Heemin Kang, and co-workers report template-mediated in situ tuning of nanoligand size and spacing. They demonstrate that submolecular ligand spacing and magnetic ligand anchoring facilitate adhesion-structure assembly-mediated pro-healing polarization of host macrophages. Increasing the ligand spacing significantly suppresses macrophage adhesion whereas increasing both ligand size and spacing slightly inhibits it.