Molecular bowls for inclusion complexation of toxic anticancer drug methotrexate
Pratik Karmakar, Tyler J. Finnegan, Darian C. Rostam, Sagarika Taneja, Sefa Uçar, Alexandar L. Hansen, Curtis E. Moore, Christopher M. Hadad, Kornkanya Pratumyot, Jon R. Parquette, Jovica D. Badjić
Abstract
is the strongest binder of MTX reported to date, we envision it as an excellent candidate for further studies on the way toward developing an antidote capable of removing MTX from overdosed cancer patients.
Topics & Concepts
DrugMethotrexatePharmacologyAnticancer drugInclusion (mineral)ChemistryMedicineInternal medicineMineralogySupramolecular Chemistry and ComplexesCrystallography and molecular interactionsSupramolecular Self-Assembly in Materials