A Comprehensive Review on Function of miR-15b-5p in Malignant and Non-Malignant Disorders
Soudeh Ghafouri‐Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Hazha Hadayat Jamal, Mohammad Taheri, Mohammadreza Hajiesmaeili
Abstract
gene. This gene is located on cytogenetic band 3q25.33. This miRNA participates in the pathogenesis of several cancers as well as non-malignant conditions, such as abdominal aortic aneurysm, Alzheimer's and Parkinson's diseases, cerebral ischemia reperfusion injury, coronary artery disease, dexamethasone induced steatosis, diabetic complications and doxorubicin-induced cardiotoxicity. In malignant conditions, both oncogenic and tumor suppressor impacts have been described for miR-15b-5p. Dysregulation of miR-15b-5p in clinical samples has been associated with poor outcome in different kinds of cancers. In this review, we discuss the role of miR-15b-5p in malignant and non-malignant conditions.