Design and synthesis of novel Thiazolo[5,4-b]pyridine derivatives as potent and selective EGFR-TK inhibitors targeting resistance Mutations in non-small cell lung cancer
Avinash S. Borude, Santosh Rangnath Deshmukh, Shailee V. Tiwari, S. Hemant Kumar, Shankar R. Thopate
Topics & Concepts
ChemistryPyridineStereochemistryMTT assayPotencyCell cultureChemical synthesisLead compoundCombinatorial chemistryCancer cellCell growthIn vitroCancerBiochemistryMedicinal chemistryMedicineInternal medicineGeneticsBiologySynthesis and biological activitySynthesis and Biological EvaluationMulticomponent Synthesis of Heterocycles