Copper‐Catalyzed Regioselective Borocarbonylative Coupling of Unactivated Alkenes with Alkyl Halides: Synthesis of β‐Boryl Ketones
Fu‐Peng Wu, Yang Yuan, Claas Schünemann, Paul C. J. Kamer, Xiao‐Feng Wu
Abstract
The borocarbonylative coupling of unactivated alkenes with alkyl halides remains a challenge. In this communication, a Cu-catalyzed borocarbonylative coupling of unactivated alkenes with alkyl halides for the synthesis of β-boryl ketones has been developed. A broad range of β-boryl ketone derivatives was prepared in moderate to excellent yields with complete regioselectivity.
Topics & Concepts
RegioselectivityAlkylHalideChemistryKetoneCatalysisOrganic chemistryCoupling (piping)Coupling reactionMedicinal chemistryMaterials scienceMetallurgyOrganoboron and organosilicon chemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions